Aortic aneurysm NICE guideline consultation

NICE has published its draft consultation document on the diagnosis and management of abdominal aortic aneurysm (AAA).
The document covers diagnosis, initial management, transfer to specialised services and surgical management. Particular emphasis is given to early identification as the prognosis for ruptured aneurysms is poor.
Screening for …

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FDA warning on new drugs in urothelial cancer

Pembrolizumab and atezolizumab are showing decreased survival compared to comparators in two trials in metastatic urothelial cancer.
Data monitoring committees for the KEYNOTE-361 and IMVIGOR-130 trials testing the drugs in patients who have not received prior therapy and who have low expression of the protein programmed …

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HPV vaccination for boys – parliamentary debate

MPs from all sides of the House of Commons called for boys to receive the HPV vaccine in a recent parliamentary debate.
With a decision from the Joint Committee on Vaccination and Immunisation (JCVI) on HPV vaccination for boys expected this year, possibly by the summer, …

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Sir Roger Bannister: Obituary

‘He made the impossible possible.’ Lord Sebastian Coe
Roger Bannister was not only a famous sportsman, but also a distinguished neurologist, specialising in rare but debilitating diseases such as multiple system atrophy (MSA) a disorder characterised by progressive degeneration of the autonomic nervous system, as well …

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Anticholinergics and dementia

Antidepressant, urological, and antiparkinson drugs with strong anticholinergic activity are linked to future dementia incidence. The link is evident with drug use up to 20 years prior to diagnosis of dementia, according to case-control study published in the British Medical Journal (doi.org/10.1136/bmj.k1315).
Anticholinergic drugs used to …

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Statins ‘remarkably safe’

Long-term statin therapy is ‘remarkably safe’ according to a consensus panel of experts reviewing data over the last 17 years.
A modest risk of new onset diabetes mellitus (1/1000 patients per year of exposure) is offset by the benefit of avoiding five new cardiovascular events, says …

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Selenium doesn’t prevent prostate cancer

Selenium supplements do not reduce the risk of any cancers, including prostate cancer, a recent Cochrane review has confirmed (http://cochranelibrary-wiley.com/doi/10.1002/14651858.CD005195.pub4/abstract).
The latest review to investigate this long-standing issue included 10 randomised-controlled trials (RCTs) and 70 observational studies in which adults were followed over time to determine …

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NSAIDs and cardiovascular risk

Nonselective nonsteroidal anti-inflammatory drugs (NSAIDs) increase the risk of heart attack and stroke in patients with rheumatoid arthritis (RA) according to a large Taiwanese study published in the American Journal of Cardiology (https://doi.org/10.1016/j.amjcard.2018.01.044)
Investigators conducted a case-crossover study of 5921 stroke or myocardial infarction (MI) patients …

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Early flagging of colorectal cancer

A smart computer algorithm that interrogates patient data to identify patients at high risk of colorectal cancer has been reviewed by NICE (https://www.nice.org.uk/advice/mib142/chapter/Summary).
The ColonFlag algorithm uses existing datasets containing age, sex and blood test results to generate a risk score for a person. People with …

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£75 million for prostate cancer

The Prime Minister, Theresa May, has promised £75 million for research focused on getting prostate cancer diagnosed earlier and faster. The research will investigate innovative treatments and new studies will particularly target higher-risk groups – including black men, men aged 50 or over and men with …

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