Long-term testosterone benefits
Long-term testosterone treatment can improve sexual and urinary function in men with hypogonadism, according to a study published in The Journal of Urology (doi:10.1016/j.juro.2017.07.039).
Investigators evaluated data on men with total testosterone levels of 12.1nmol/L or less and symptoms of hypogonadism assigned to parenteral testosterone undecanoate 1000mg every 12 weeks (n=360; mean age, 57.4 years) or no testosterone (n=296; mean age, 64.8 years) for up to 10 years to determine the effect of long-term testosterone therapy on urinary and sexual function and quality of life. Follow-up was a mean of 6.5 years.
Total testosterone levels were restored to the physiological range (500 ng/dL) in the treated group during the first year and the levels remained stable through follow-up; mean testosterone levels remained less than 300ng/dL in the untreated group.
The untreated group experienced increases in the International Prostate Symptom Score during follow-up compared with decreases in the treated group.
Post-voiding bladder volume and score on the Aging Males’ Symptoms Scale decreased in the treated group but increased in the untreated group.
There was significant improvement in the International Index of Erectile Function – Erectile Function domain (IIEF-EF) (p<0.0001) in the treated group, but not in the untreated group, and this was maintained throughout the follow-up period.
Prostate volume remained stable in the untreated group but increased from 31.4 mL to 33.2mL in the treated group.