NICE holds back on wider use of innovative prostate cancer drugs

NICE has provoked controversy with its decisions on whether the NHS should fund new treatments for prostate cancer, and at what stage of the treatment pathway they should be used.
NICE has recommended the androgen receptor signalling inhibitor enzalutamide (Xtandi) for the treatment of metastatic prostate …

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Sexual dysfunction common in US military

One in 12 young US military personnel reports problems with sexual function, a US analysis has found (J Sex Med 2014; doi: 10.1111/jsm.12643).
The study was an exploratory analysis of a nationwide survey carried out in 2013. It identified 367 male military personnel aged 40 or …

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Benefits of PSA screening may not outweigh harms

More information about the potential harm of PSA testing is needed before a screening programme is introduced, says Prostate Cancer UK, even though such a programme could reduce deaths by 25 per cent in the long term.
The European Randomised study of Screening for Prostate Cancer …

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Risk factors predict renal scarring in childhood UTI

A large international study has identified clinical signs that predict the risk of renal scarring in children who have a urinary tract infection (JAMA Pediatrics 2014; doi:10.1001/jamapediatrics.2014.637).
The meta-analysis of nine studies involving a total of 1280 children and young people with urinary tract infection found …

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Unrecognised complications increase urological surgery mortality

Failing to recognise complications after urological surgery appears to be an important contributor to the risk of death, a US study shows (BJU Int 2014; doi:10.1111/bju.12833). 
The analysis of 7.7 million urological procedures carried out between 1998 and 2010 revealed a small but statistically significant reduction …

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Erectile dysfunction undertreated

Only a quarter of men diagnosed with erectile dysfunction obtain drug treatment, according to a US study (J Sex Med 2014; doi: 10.1111/jsm.12647).
The analysis of a medical insurance database identified over 6 million men aged 30 or older with a recorded diagnosis of erectile dysfunction …

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Genetic screening identifies high-risk prostate cancer

It has long been known that mutations of the BRCA2 gene are associated with aggressive prostate cancer but only now has it been shown that screening for this abnormality could identify men at increased risk (Br J Cancer 2014; doi: 10.1038/bjc.2014.428).
Canadian investigators identified 4187 men …

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HoLEP improves LUTS without affecting sexual function

Holmium laser enucleation of the prostate (HoLEP) improves lower urinary tract symptom (LUTS) scores in men with benign prostatic hyperplasia without significantly affecting sexual function, two recent studies show.
A prospective study compared pre- and postoperative sexual function and LUTS scores in 60 men (Asian J …

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