New PrEP approaches needed

New drugs, technologies and delivery systems for pre-exposure prophylaxis (PrEP) against HIV infection are needed that can provide protection for a wide variety of people with different needs over the course of their sexually active lifespan, according to a paper in The Lancet HIV (doi.org/10.1016/S2352-3018(19)30238-3)
Pre-exposure …

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Five-year melanoma survival boost with drug combo

A combination of two immunotherapy drugs can increase overall survival in advanced melanoma to over 50% at five years.
The results of the CheckMate 067 trial published in The New England Journal of Medicine (DOI: 10.1056/NEJMoa1910836) show that overall survival at five years was 52% in …

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Addition of apalutamide incurs no QOL cost

Adding apalutamide to standard androgen deprivation therapy (ADT) in patients with metastatic castration-sensitive prostate cancer does not adversely affect overall quality of life (QOL), including pain and fatigue.
The phase 3 TITAN study showed that the addition of apalutamide to ADT significantly improved overall survival and …

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Urology Awareness Month

Trends in Urology and Men’s Health was very happy to join numerous organisations to help celebrate Urology Awareness Month, a campaign that aims to raise awareness around urological conditions and the innovations in treatment, importance of diagnosis and prevention of all urological conditions.
The campaign was …

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New HIV diagnoses fall by almost a third

Since 2015 the rate of new HIV diagnoses in the UK has fallen by almost a third (28%) from 6271 to 4484 in 2018, according to recent data published by Public Health England (PHE). 
The 2018 figure is the lowest recorded rate of new HIV diagnosis …

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NICE updates hypertension guidelines

The National Institute for Health and Care Excellence (NICE) has recently published its updated guidance on the diagnosis and management of hypertension in adults (NG136).
The guidance update has caused some controversy as it maintains the previous definition of hypertension as a blood pressure reading of …

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NICE recommends antiseptics over antibiotics for impetigo

Localised, non-bullous impetigo should be treated with a topical antiseptic rather than an antibiotic, according to new draft guidance published by the National Institute for Health and Care Excellence (NICE) and Public Health England (PHE).
The decision comes as a result of a review by NICE …

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First chlamydia vaccine shows early success

The first experimental chlamydia vaccine to ever reach a phase 1 clinical trial has been shown to be tolerably safe and to provoke an immune response, according to a recent study published in The Lancet Infectious Diseases.
The vaccine, known as CTH522, was administered as an …

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NSAID use increases CVD risk in osteoarthritis

Non-steroidal anti-inflammatory drug (NSAID) use in patients with osteoarthritis is associated with an increased risk of cardiovascular disease (CVD), according to the results of a recent longitudinal study.
Osteoarthritis (OA) is already recognised as an independent risk factor for increased CVD, yet the underlying mechanism for …

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Higher oestrogen levels in the womb linked with autism

A recent study, published in Molecular Psychiatry, has suggested that elevated levels of oestrogen during pregnancy is linked to the development of autism spectrum disorder in the foetus.
The study, which was conducted by scientists at the University of Cambridge and the State Serum Institute in …

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