Psoriasis linked to sexual dysfunction

Psoriasis could increase the risk of sexual dysfunction (SD), including erectile dysfunction (ED), particularly in patients with psychological comorbidity, according to a recent systematic review published in JAMA Dermatology (2019;155:98–106).
The review included 28 studies including 52 520 cases of psoriasis and 1 806 022 controls. Two …

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First immunotherapy approved for renal cell cancer

The European Union (EU) has approved the combination of nivolumab plus ipilimumab for the first-line treatment of patients with intermediate- and poor-risk advanced renal cell carcinoma (RCC). This is the first approval of immunotherapy for RCC in the EU.
The approval is based on results from …

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Prostatectomy benefit confirmed

Radical prostatectomy improves survival compared with watchful waiting in otherwise healthy men with localised prostate cancer, according to a 28-year follow-up study published in the New England Journal of Medicine (2018;379:2319–29).
Researchers randomly assigned 695 men with localised prostate cancer to watchful waiting or radical prostatectomy …

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Cultural activity fends off depression in old age

Visiting museums, the cinema and theatre are associated with a lower risk of developing depression in older people.
A study published in the British Journal of Psychiatry (doi.org/10.1192/bjp.2018.267) looked at data from 2148 adults, mean age 62.9 years (range 52–89), in the English Longitudinal Study of …

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Testosterone not associated with VTE

Prescribed testosterone in men is not associated with venous thromboembolism (VTE), according to a meta-analysis published in Thrombosis Research (2018;172:94­–103).
The analysis used six randomised clinical trials (n=2236), the majority in men with hypogonadism, and five observational studies (n=1 249 640). There was no evidence of …

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NICE approves multiparametric MRI for prostate cancer

NICE has recommended multiparametric MRI (mpMRI) as a first-line investigation for men with suspected clinically localised prostate cancer. Used alongside PSA testing the scanning technique will help identify cancers and prevent unnecessary prostate biopsies.
mpMRI can produce a detailed image of the prostate which can help …

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Cardio and renal benefits with diabetes drugs

A meta-analysis of three large randomised controlled clinical trials has shown significant cardiovascular and renal benefits of sodium-glucose co-transporter-2 inhibitors (SGLT2I) in patients with type 2 diabetes.
The study, published in the Lancet (doi.org/10.1016/S0140-6736(18)32590-X), found that SGLT2I reduced major adverse cardiovascular events (myocardial infarction, stroke, or …

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North-south divide on deaths

An excess of 3530 men aged 25–44 are dying from cardiovascular disease, accidents, and alcohol and drug misuse in the north of England compared to the south, and the gap shows no sign of narrowing.
According to the study published in the Lancet Public Health (doi.org/10.1016/S2468-2667(18)30177-4) …

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New antibiotic for gonorrhoea on trial

A novel single-dose oral antibiotic (zoliflodacin) has been shown to be effective against gonorrhoea infections. In a study published in the New England Journal of Medicine (doi.10.1056/NEJMoa1706988) trialists randomly assigned 179 men and women with signs or symptoms of uncomplicated urogenital gonorrhoea to a single …

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Active drugs found in supplements

Testing of unlicensed supplements that claim to boost sexual performance, and supplements that claim to help build muscle, shows that a significant number contain active prescription drugs.
Data reported by the US FDA reveals that 80% of adulterated sexual supplements contained sildenafil or a close analogue. …

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