Prostate cancer survival predictor launched

A tool that helps patients with nonmetastatic prostate cancer choose watchful waiting or more radical treatment is available to men and the healthcare professionals treating them. The Predict Prostate tool went live on an NHS website on 13 March.
The study demonstrating the accuracy of the …

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NICE lowers BP treatment threshold

Many thousands more people are set to receive treatment for hypertension following publication of new draft guidance from NICE.
The revised guideline recommends that antihypertensive drugs should be given to people aged under 80 with a diagnosis of stage 1 hypertension who have a 10% or …

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Prostvac disappoints in phase 3 trial

The tailored prostate cancer vaccine, Prostvac, has failed to show any benefit in overall survival (OS) compared to placebo in patients with metastatic castration-resistant prostate cancer (mCRPC). Secondary end points of radiographic progression, pain progression or chemotherapy initiation also showed no benefit. Combining the treatment …

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BMA fence-sits on circumcision

The fraught issue of non-therapeutic male circumcision is addressed in a toolkit for doctors published by the BMA.
The toolkit provides practical guidance to doctors who may be asked to refer a child for non-therapeutic male circumcision or to carry out circumcision themselves. As with other …

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General health checks don’t work

General health checks have little or no effect on the risk of death from any cause or on the risk of death from cancer and probably have little or no effect on the risk of death from cardiovascular causes, according to a recent Cochrane review …

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Supplements and semen quality

Some drugs and nutritional supplements can improve semen quality but there is little evidence that it leads to improved pregnancy rates, according to a paper published in European Urology (doi.org/10.1016/j.eururo.2018.12.022).
A large analysis of 61 published studies found that pentoxyfylline, coenzyme Q10, L-carnitine, follicle-stimulating hormone, tamoxifen, …

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Statins only work if you take them

A large study has shown that adherence to statins is highly variable and that they only reduce mortality if they are taken regularly. The good news for men is that they are more likely than women to take their statin regularly.
In this large study from …

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Early age cannabis use and depression link

Cannabis is the most commonly used drug of abuse by adolescents in the world, particularly boys. While the impact of adolescent cannabis use on the development of psychosis has been investigated in depth, little is known about the impact of cannabis use on mood and …

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Ambitious targets for ABC

A new coalition led by Public Health England (PHE) and NHS England has announced national ambitions to improve the detection and treatment of atrial fibrillation, high blood pressure and high cholesterol (the A-B-C conditions).
The National CVD Prevention System Leadership Forum is made up of over …

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Apalutamide gains licence

The European Commission (EC) has licensed the second-generation oral androgen receptor inhibitor apalutamide (Erleada) for the treatment of men with nonmetastatic castration-resistant prostate cancer who are at high risk of developing metastatic disease.
The licence is based on the results of the phase 3 SPARTAN trial, …

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