Family history predicts major events in ED

A family history of cardio-metabolic diseases in men with erectile dysfunction (ED) is a strong predictor of future major adverse cardiovascular events.

In this US study, researchers looked at data from 4693 men with ED attending an andrology clinic. Family history, cardiovascular health at presentation and subsequent major cardiovascular events were analysed.

A greater number of cardio-metabolic family history factors were associated with a worse metabolic profile, including higher waist circumference, triglycerides, glucose, glycosylated haemoglobin, and diastolic blood pressure, as well as lower high-density lipoprotein cholesterol. A strong family history was associated with worse ED.

Looking at subsequent major cardiovascular events a positive cardiometabolic family history was associated with a significantly higher incidence of events, even after adjusting for age and comorbidities (hazard ratio = 1.51[1.06­–2.16], p= 0.023).

According to the authors investigating family history for cardio-metabolic diseases in ED patients is a quick and easy task that could help identify those at risk of serious cardiovascular events and who, according to conventional CV risk factors, would be erroneously considered at low risk.

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