PrEP trial expansion calls

Calls have been made for the pre-exposure HIV prophylaxis (PrEP) trial – looking at the effectiveness and practicalities of introducing a PrEP programme in the UK – to double in size from 13 000 participants to 26 000.
Some reports say that demand has been so …

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Erectile dysfunction cream eye error

Doctors in Glasgow have reported a case of an erectile dysfunction cream (Vitaros) being given to a women in error instead of an ocular lubricant (VitA-POS) (BMJ doi:10.1136/bcr-2018-227468). The woman applied the cream and suffered mild chemical injury to her eyes that responded to topical …

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Resistant gonorrhoea identified in UK

Public Health England (PHE) is investigating two cases of Neisseria gonorrhoeae in heterosexual females that is resistant to first-line antibiotics, ceftriaxone and azithromycin.
According to PHE, both cases were successfully treated and it is now following up sexual contacts of the patients to minimise the risk …

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Mental health of men and boys: call for evidence

The UK Parliament Women and Equalities Committee’s inquiry into the mental health of men and boys launched in November last year and is inviting written submissions. The Men’s Health Forum, which campaigns strongly for more support for mental health issues in men and boys, is …

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Psoriasis linked to sexual dysfunction

Psoriasis could increase the risk of sexual dysfunction (SD), including erectile dysfunction (ED), particularly in patients with psychological comorbidity, according to a recent systematic review published in JAMA Dermatology (2019;155:98–106).
The review included 28 studies including 52 520 cases of psoriasis and 1 806 022 controls. Two …

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First immunotherapy approved for renal cell cancer

The European Union (EU) has approved the combination of nivolumab plus ipilimumab for the first-line treatment of patients with intermediate- and poor-risk advanced renal cell carcinoma (RCC). This is the first approval of immunotherapy for RCC in the EU.
The approval is based on results from …

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Prostatectomy benefit confirmed

Radical prostatectomy improves survival compared with watchful waiting in otherwise healthy men with localised prostate cancer, according to a 28-year follow-up study published in the New England Journal of Medicine (2018;379:2319–29).
Researchers randomly assigned 695 men with localised prostate cancer to watchful waiting or radical prostatectomy …

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Cultural activity fends off depression in old age

Visiting museums, the cinema and theatre are associated with a lower risk of developing depression in older people.
A study published in the British Journal of Psychiatry (doi.org/10.1192/bjp.2018.267) looked at data from 2148 adults, mean age 62.9 years (range 52–89), in the English Longitudinal Study of …

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Testosterone not associated with VTE

Prescribed testosterone in men is not associated with venous thromboembolism (VTE), according to a meta-analysis published in Thrombosis Research (2018;172:94­–103).
The analysis used six randomised clinical trials (n=2236), the majority in men with hypogonadism, and five observational studies (n=1 249 640). There was no evidence of …

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NICE approves multiparametric MRI for prostate cancer

NICE has recommended multiparametric MRI (mpMRI) as a first-line investigation for men with suspected clinically localised prostate cancer. Used alongside PSA testing the scanning technique will help identify cancers and prevent unnecessary prostate biopsies.
mpMRI can produce a detailed image of the prostate which can help …

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