Testosterone not associated with VTE

Prescribed testosterone in men is not associated with venous thromboembolism (VTE), according to a meta-analysis published in Thrombosis Research (2018;172:94­–103).

The analysis used six randomised clinical trials (n=2236), the majority in men with hypogonadism, and five observational studies (n=1 249 640). There was no evidence of a statistically significant association between VTE and testosterone (odds ratio 1.41, 95% CI 0.96–2.07).

Some regulatory bodies, including the US FDA, have warned about an increased risk of VTE in people prescribed testosterone; however, the published clinical data supporting an increased risk for VTE are limited.

According to the authors, the current evidence is of low certainty but does not support an association between testosterone use and VTE in men.

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